Anti-LOXL1 antibody (95-370) (STJ112229)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LOXL1 (95-370) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LOXL1 |
| Gene ID | 4016 |
| Uniprot ID | LOXL1_HUMAN |
| Immunogen Region | 95-370 |
| Immunogen Sequence | RQAPSLPLPGRVGSDTVRGQ ARHPFGFGQVPDNWREVAVG DSTGMARARTSVSQQRHGGS ASSVSASAFASTYRQQPSYP QQFPYPQAPFVSQYENYDPA SRTYDQGFVYYRPAGGGVGA GAAAVASAGVIYPYQPRARY EEYGGGEELPEYPPQGFYPA PERPYVPPPPPPPDGLDRRY SHSLYSEGTPGFEQAYPDPG PEAAQAHGGDPRLGWYPPYA NPPPEAYGPPRALEPPYLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2). |
Additional Info
| Tissue Specificity | Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic processing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Protein Name | Lysyl Oxidase Homolog 1Lysyl Oxidase-Like Protein 1Lol |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Lysyl Oxidase Homolog 1 antibodyAnti-Lysyl Oxidase-Like Protein 1 antibodyAnti-Lol antibodyAnti-LOXL1 antibodyAnti-LOXL antibody |
Information sourced from Uniprot.org