Anti-LONP1 antibody (398-448 aa) (STJ193711)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LONM at the amino acid range 398-448
General Information
| Short Description | Rabbit polyclonal anti-Lon protease homolog, mitochondrial (398-448 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LONP1 |
| Gene ID | 9361 |
| Uniprot ID | LONM_HUMAN |
| Immunogen | Synthesized peptide derived from the human LONM at the amino acid range 398-448 |
| Immunogen Region | 398-448 aa |
| Specificity | This antibody detects endogenous levels of LONM at Human/Mouse/Rat |
Additional Info
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. |
| Protein Name | Lon Protease Homolog - MitochondrialLonhsLon Protease-Like ProteinLonpMitochondrial Atp-Dependent Protease LonSerine Protease 15 |
| Database Links | Reactome: R-HSA-9837999Reactome: R-HSA-9841251 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Lon Protease Homolog - Mitochondrial antibodyAnti-Lonhs antibodyAnti-Lon Protease-Like Protein antibodyAnti-Lonp antibodyAnti-Mitochondrial Atp-Dependent Protease Lon antibodyAnti-Serine Protease 15 antibodyAnti-LONP1 antibodyAnti-PRSS15 antibody |
Information sourced from Uniprot.org