| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase LNX (527-577) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LNX1 |
| Gene ID: |
84708 |
| Uniprot ID: |
LNX1_HUMAN |
| Immunogen Region: |
527-577 |
| Specificity: |
This antibody detects endogenous levels of human LNX1 |
| Immunogen: |
Synthesized peptide derived from human LNX1 AA range: 527-577 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. |
| Protein Name | E3 Ubiquitin-Protein Ligase LnxLigand Of Numb-Protein X 1Numb-Binding Protein 1Pdz Domain-Containing Ring Finger Protein 2Ring-Type E3 Ubiquitin Transferase Lnx |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lnx antibodyAnti-Ligand Of Numb-Protein X 1 antibodyAnti-Numb-Binding Protein 1 antibodyAnti-Pdz Domain-Containing Ring Finger Protein 2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lnx antibodyAnti-LNX1 antibodyAnti-LNX antibodyAnti-PDZRN2 antibodyAnti-UNQ574 antibodyAnti-PRO1136 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
