| Short Description : | Rabbit polyclonal anti-LIM and cysteine-rich domains protein 1 (270-320 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMCD1 |
| Gene ID: | 29995 |
| Uniprot ID: | LMCD1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human LMCD1 at the amino acid range 270-320 |
| Immunogen Region: | 270-320 aa |
| Specificity: | This antibody detects endogenous levels of LMCD1 at Human/Mouse |
| Function | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. |
| Protein Name | Lim And Cysteine-Rich Domains Protein 1Dyxin |
| Database Links | Reactome: R-HSA-5683826 |
| Cellular Localisation | CytoplasmNucleusMay Shuttle Between The Cytoplasm And The Nucleus |
| Alternative Antibody Names | Anti-Lim And Cysteine-Rich Domains Protein 1 antibodyAnti-Dyxin antibodyAnti-LMCD1 antibody |
Information sourced from Uniprot.org
