| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Lysosomal cobalamin transport escort protein LMBD1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMBRD1 |
| Gene ID: | 55788 |
| Uniprot ID: | LMBD1_HUMAN |
| Specificity: | This antibody detects endogenous levels of LMBRD1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human LMBRD1 |
| Post Translational Modifications | N-glycosylated. |
| Function | Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane. Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2. Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis. Isoform 3: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). |
| Protein Name | Lysosomal Cobalamin Transport Escort Protein Lmbd1 Lmbd1 Hdag-L-Interacting Protein Nesi Lmbr1 Domain-Containing Protein 1 Nuclear Export Signal-Interacting Protein |
| Database Links | Reactome: R-HSA-5683329 Reactome: R-HSA-9758881 Reactome: R-HSA-9758890 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Lysosome Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasmic Vesicle Clathrin-Coated Vesicle |
| Alternative Antibody Names | Anti-Lysosomal Cobalamin Transport Escort Protein Lmbd1 antibody Anti-Lmbd1 antibody Anti-Hdag-L-Interacting Protein Nesi antibody Anti-Lmbr1 Domain-Containing Protein 1 antibody Anti-Nuclear Export Signal-Interacting Protein antibody Anti-LMBRD1 antibody Anti-C6orf209 antibody Anti-NESI antibody Anti-BM-021 antibody Anti-CD001 antibody Anti-MSTP044 antibody |
Information sourced from Uniprot.org