| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LMBRD1 (220-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LMBRD1 |
| Gene ID: |
55788 |
| Uniprot ID: |
LMBD1_HUMAN |
| Immunogen Region: |
220-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-300 of human LMBRD1 (NP_060838.3). |
| Immunogen Sequence: |
PLNLIKGTRSAAYERLENTE DIEEVEQHIQTIKSKSKDGR PLPARDKRALKQFEERLRTL KKRERHLEFIENSWWTKFCG A |
| Tissue Specificity | Isoform 3 is expressed in liver. |
| Post Translational Modifications | N-glycosylated. |
| Function | Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane. Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2. Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis. Isoform 3: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). |
| Protein Name | Lysosomal Cobalamin Transport Escort Protein Lmbd1Lmbd1Hdag-L-Interacting Protein NesiLmbr1 Domain-Containing Protein 1Nuclear Export Signal-Interacting Protein |
| Database Links | Reactome: R-HSA-5683329Reactome: R-HSA-9758881Reactome: R-HSA-9758890 |
| Cellular Localisation | Endoplasmic Reticulum MembraneLysosome MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic VesicleClathrin-Coated Vesicle |
| Alternative Antibody Names | Anti-Lysosomal Cobalamin Transport Escort Protein Lmbd1 antibodyAnti-Lmbd1 antibodyAnti-Hdag-L-Interacting Protein Nesi antibodyAnti-Lmbr1 Domain-Containing Protein 1 antibodyAnti-Nuclear Export Signal-Interacting Protein antibodyAnti-LMBRD1 antibodyAnti-C6orf209 antibodyAnti-NESI antibodyAnti-BM-021 antibodyAnti-CD001 antibodyAnti-MSTP044 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
