Anti-LITAF antibody (STJ192296)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Lipopolysaccharide-induced tumor necrosis factor-alpha factor for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LITAF |
| Gene ID | 9516 |
| Uniprot ID | LITAF_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | LITAF Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to EGF. |
| Function | Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. |
| Protein Name | Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha FactorLps-Induced Tnf-Alpha FactorSmall Integral Membrane Protein Of Lysosome/Late EndosomeP53-Induced Gene 7 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLysosome MembranePeripheral Membrane ProteinCytoplasmic SideEarly Endosome MembraneLate Endosome MembraneEndosome MembraneCell MembraneGolgi Apparatus MembraneAssociated With Membranes Of LysosomesEarly And Late EndosomesCan Translocate From The Cytoplasm Into The NucleusDetected At Schmidt-Lanterman Incisures And In Nodal Regions Of Myelinating Schwann Cells |
| Alternative Antibody Names | Anti-Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor antibodyAnti-Lps-Induced Tnf-Alpha Factor antibodyAnti-Small Integral Membrane Protein Of Lysosome/Late Endosome antibodyAnti-P53-Induced Gene 7 Protein antibodyAnti-LITAF antibodyAnti-PIG7 antibodyAnti-SIMPLE antibody |
Information sourced from Uniprot.org