| Host: |
Rabbit |
| Applications: |
WB/IHC/IP |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LITAF (1-161) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IP 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LITAF |
| Gene ID: |
9516 |
| Uniprot ID: |
LITAF_HUMAN |
| Immunogen Region: |
1-161 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LITAF (NP_004853.2). |
| Immunogen Sequence: |
MSVPGPYQAATGPSSAPSAP PSYEETVAVNSYYPTPPAPM PGPTTGLVTGPDGKGMNPPS YYTQPAPIPNNNPITVQTVY VQHPITFLDRPIQMCCPSCN KMIVSQLSYNAGALTWLSCG SLCLLGCIAGCCFIPFCVDA LQDVDHYCPNCRALLGTYKR L |
| Tissue Specificity | Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to EGF. |
| Function | Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. |
| Protein Name | Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha FactorLps-Induced Tnf-Alpha FactorSmall Integral Membrane Protein Of Lysosome/Late EndosomeP53-Induced Gene 7 Protein |
| Cellular Localisation | CytoplasmNucleusLysosome MembranePeripheral Membrane ProteinCytoplasmic SideEarly Endosome MembraneLate Endosome MembraneEndosome MembraneCell MembraneGolgi Apparatus MembraneAssociated With Membranes Of LysosomesEarly And Late EndosomesCan Translocate From The Cytoplasm Into The NucleusDetected At Schmidt-Lanterman Incisures And In Nodal Regions Of Myelinating Schwann Cells |
| Alternative Antibody Names | Anti-Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor antibodyAnti-Lps-Induced Tnf-Alpha Factor antibodyAnti-Small Integral Membrane Protein Of Lysosome/Late Endosome antibodyAnti-P53-Induced Gene 7 Protein antibodyAnti-LITAF antibodyAnti-PIG7 antibodyAnti-SIMPLE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
