Anti-LIPC antibody (280-499) (STJ115469)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LIPC (280-499) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LIPC |
| Gene ID | 3990 |
| Uniprot ID | LIPC_HUMAN |
| Immunogen Region | 280-499 |
| Immunogen Sequence | ERSVHLFIDSLLHAGTQSMA YPCGDMNSFSQGLCLSCKKG RCNTLGYHVRQEPRSKSKRL FLVTRAQSPFKVYHYQFKIQ FINQTETPIQTTFTMSLLGT KEKMQKIPITLGKGIASNKT YSFLITLDVDIGELIMIKFK WENSAVWANVWDTVQTIIPW STGPRHSGLVLKTIRVKAGE TQQRMTFCSENTDDLLLRPT QEKIFVKCEIKSKTSKRKIR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2). |
Additional Info
| Function | Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position. |
| Protein Name | Hepatic Triacylglycerol LipaseHlHepatic LipaseLipase Member CLysophospholipasePhospholipase A1 |
| Database Links | Reactome: R-HSA-8963889Reactome: R-HSA-8964026 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Hepatic Triacylglycerol Lipase antibodyAnti-Hl antibodyAnti-Hepatic Lipase antibodyAnti-Lipase Member C antibodyAnti-Lysophospholipase antibodyAnti-Phospholipase A1 antibodyAnti-LIPC antibodyAnti-HTGL antibody |
Information sourced from Uniprot.org