Anti-LINGO1 antibody (42-240) (STJ111679)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LINGO1 (42-240) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LINGO1 |
| Gene ID | 84894 |
| Uniprot ID | LIGO1_HUMAN |
| Immunogen Region | 42-240 |
| Immunogen Sequence | CPPRCECSAQDRAVLCHRKR FVAVPEGIPTETRLLDLGKN RIKTLNQDEFASFPHLEELE LNENIVSAVEPGAFNNLFNL RTLGLRSNRLKLIPLGVFTG LSNLTKLDISENKIVILLDY MFQDLYNLKSLEVGDNDLVY ISHRAFSGLNSLEQLTLEKC NLTSIPTEALSHLHGLIVLR LRHLNINAIRDYSFKRLYR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 42-240 of human LINGO1 (NP_116197.4). |
Additional Info
| Tissue Specificity | Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. |
| Post Translational Modifications | N-glycosylated. Contains predominantly high-mannose glycans. |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. |
| Protein Name | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1Leucine-Rich Repeat Neuronal Protein 1Leucine-Rich Repeat Neuronal Protein 6a |
| Database Links | Reactome: R-HSA-193634 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 antibodyAnti-Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 antibodyAnti-Leucine-Rich Repeat Neuronal Protein 1 antibodyAnti-Leucine-Rich Repeat Neuronal Protein 6a antibodyAnti-LINGO1 antibodyAnti-LERN1 antibodyAnti-LRRN6A antibodyAnti-UNQ201 antibodyAnti-PRO227 antibody |
Information sourced from Uniprot.org