| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leukocyte immunoglobulin-like receptor subfamily B member 3 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LILRB3 |
| Gene ID: | 102725035/107987462 |
| Uniprot ID: | LIRB3_HUMAN |
| Specificity: | LIRB3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 Lir-3 Leukocyte Immunoglobulin-Like Receptor 3 Cd85 Antigen-Like Family Member A Immunoglobulin-Like Transcript 5 Ilt-5 Monocyte Inhibitory Receptor Hl9 Cd Antigen Cd85a |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibody Anti-Lir-3 antibody Anti-Leukocyte Immunoglobulin-Like Receptor 3 antibody Anti-Cd85 Antigen-Like Family Member A antibody Anti-Immunoglobulin-Like Transcript 5 antibody Anti-Ilt-5 antibody Anti-Monocyte Inhibitory Receptor Hl9 antibody Anti-Cd Antigen Cd85a antibody Anti-LILRB3 antibody Anti-ILT5 antibody Anti-LIR3 antibody |
Information sourced from Uniprot.org