Anti-LILRB1/CD85j antibody (24-458 aa) [SRM5384] (STJ11107295)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal LILRB1/CD85j (24-458 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5384 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRB1 |
| Gene ID | 10859 |
| Uniprot ID | LIRB1_HUMAN |
| Immunogen Region | 24-458 aa |
| Immunogen Sequence | GHLPKPTLWAEPGSVITQGS PVTLRCQGGQETQEYRLYRE KKTAPWITRIPQELVKKGQF PIPSITWEHTGRYRCYYGSD TAGRSESSDPLELVVTGAYI KPTLSAQPSPVVNSGGNVTL QCDSQVAFDGFILCKEGEDE HPQCLNSQPHARGSSRAIFS VGPVSPSRRWWYRCYAYDSN SPYEWSLPSDLLELLVLGVS KKPSLSVQPGPIVAPEETLT LQCGSDAGYNRFVLYKDGE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-458 of human LILRB1/CD85j (NP_006660.4). |
Additional Info
| Tissue Specificity | Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level). Expressed in decidual macrophages (at protein level). Expressed in decidual NK cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1Lir-1Leukocyte Immunoglobulin-Like Receptor 1Cd85 Antigen-Like Family Member JImmunoglobulin-Like Transcript 2Ilt-2Monocyte/Macrophage Immunoglobulin-Like Receptor 7Mir-7Cd Antigen Cd85j |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 5: Secreted |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 antibodyAnti-Lir-1 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 1 antibodyAnti-Cd85 Antigen-Like Family Member J antibodyAnti-Immunoglobulin-Like Transcript 2 antibodyAnti-Ilt-2 antibodyAnti-Monocyte/Macrophage Immunoglobulin-Like Receptor 7 antibodyAnti-Mir-7 antibodyAnti-Cd Antigen Cd85j antibodyAnti-LILRB1 antibodyAnti-ILT2 antibodyAnti-LIR1 antibodyAnti-MIR7 antibody |
Information sourced from Uniprot.org