| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LILRA2 (24-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LILRA2 |
| Gene ID: |
11027 |
| Uniprot ID: |
LIRA2_HUMAN |
| Immunogen Region: |
24-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-240 of human LILRA2 (NP_006857.2). |
| Immunogen Sequence: |
GHLPKPTLWAEPGSVIIQGS PVTLRCQGSLQAEEYHLYRE NKSASWVRRIQEPGKNGQFP IPSITWEHAGRYHCQYYSHN HSSEYSDPLELVVTGAYSKP TLSALPSPVVTSGGNVTLQC VSQVAFDGFILCKEGEDEHP QRLNSHSHARGWSWAIFSVG PVSPSRRWSYRCYAYDSNSP YVWSLPSDLLELLVPGVSKK PSLSVQPGPMVAPGESL |
| Tissue Specificity | Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells. |
| Function | Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2Cd85 Antigen-Like Family Member HImmunoglobulin-Like Transcript 1Ilt-1Leukocyte Immunoglobulin-Like Receptor 7Lir-7Cd Antigen Cd85h |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 antibodyAnti-Cd85 Antigen-Like Family Member H antibodyAnti-Immunoglobulin-Like Transcript 1 antibodyAnti-Ilt-1 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 7 antibodyAnti-Lir-7 antibodyAnti-Cd Antigen Cd85h antibodyAnti-LILRA2 antibodyAnti-ILT1 antibodyAnti-LIR7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
