Anti-LGR6 antibody (850-920) {FITC} (STJ501596)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 850-920 on human LRG6 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-LGR6 (850-920) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.58-0.65 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | LGR6 |
| Gene ID | 59352 |
| Uniprot ID | LGR6_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 850-920 on human LRG6 protein. |
| Immunogen Region | 850-920 |
Additional Info
| Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. |
| Protein Name | Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 antibodyAnti-LGR6 antibodyAnti-UNQ6427 antibodyAnti-PRO21331 antibodyAnti-VTS20631 antibody |
Information sourced from Uniprot.org