Anti-LGMN antibody (100-150) {FITC} (STJ501593)

Name: Anti-LGMN antibody (100-150) {FITC} (STJ501593)
SKU: STJ501593-100
Price: 497.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationFITC

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 100-150 on human Legumain protein.

STJ501593-100

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Short Description	Rabbit polyclonal antibody anti-LGMN (100-150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	FITC
Concentration	0.5 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:150
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	LGMN
Gene ID	5641
Uniprot ID	LGMN_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 100-150 on human Legumain protein.
Immunogen Region	100-150

Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Post Translational Modifications	Activated by autocatalytic processing at pH 4.
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name	Legumain Asparaginyl Endopeptidase Aep Protease - Cysteine 1
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-196791 Reactome: R-HSA-2132295
Cellular Localisation	Lysosome
Alternative Antibody Names	Anti-Legumain antibody Anti-Asparaginyl Endopeptidase antibody Anti-Aep antibody Anti-Protease - Cysteine 1 antibody Anti-LGMN antibody Anti-PRSC1 antibody

Information sourced from Uniprot.org