Anti-LGALS8 antibody (1-100) [S4MR] (STJ11102064)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Galectin 8 (1-100) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LGALS8 |
| Gene ID | 3964 |
| Uniprot ID | LEG8_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MMLSLNNLQNIIYNPVIPFV GTIPDQLDPGTLIVIRGHVP SDADRFQVDLQNGSSMKPRA DVAFHFNPRFKRAGCIVCNT LINEKWGREEITYDTPFKRE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Galectin 8/LGALS8 (O00214). |
Additional Info
| Tissue Specificity | Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. |
| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Antibody Names | Anti-Galectin-8 antibodyAnti-Gal-8 antibodyAnti-Po66 Carbohydrate-Binding Protein antibodyAnti-Po66-Cbp antibodyAnti-Prostate Carcinoma Tumor Antigen 1 antibodyAnti-Pcta-1 antibodyAnti-LGALS8 antibody |
Information sourced from Uniprot.org