| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S1MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LGALS1 |
| Gene ID: | 3956 |
| Uniprot ID: | LEG1_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Galectin 1/LGALS1 (P09382). |
| Immunogen Sequence: | MACGLVASNLNLKPGECLRV RGEVAPDAKSFVLNLGKDSN NLCLHFNPRFNAHGDANTIV CNSKDGGAWGTEQREAVFPF QPGSVAEVCITFDQANLTVK |
| Tissue Specificity | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. |
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. |
| Protein Name | Galectin-1 Gal-1 14 Kda Laminin-Binding Protein Hlbp14 14 Kda Lectin Beta-Galactoside-Binding Lectin L-14-I Galaptin Hbl Hpl Lactose-Binding Lectin 1 Lectin Galactoside-Binding Soluble 1 Putative Mapk-Activating Protein Pm12 S-Lac Lectin 1 |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Cytoplasm Can Be Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Galectin-1 antibody Anti-Gal-1 antibody Anti-14 Kda Laminin-Binding Protein antibody Anti-Hlbp14 antibody Anti-14 Kda Lectin antibody Anti-Beta-Galactoside-Binding Lectin L-14-I antibody Anti-Galaptin antibody Anti-Hbl antibody Anti-Hpl antibody Anti-Lactose-Binding Lectin 1 antibody Anti-Lectin Galactoside-Binding Soluble 1 antibody Anti-Putative Mapk-Activating Protein Pm12 antibody Anti-S-Lac Lectin 1 antibody Anti-LGALS1 antibody |
Information sourced from Uniprot.org
