Anti-LEPREL1 antibody (400-700) (STJ110371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LEPREL1 (400-700) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | P3H2 |
| Gene ID | 55214 |
| Uniprot ID | P3H2_HUMAN |
| Immunogen Region | 400-700 |
| Immunogen Sequence | IRYGGRQDENRVPSGVNVEG AEVHGFSMGKKLSPKIDRDL REGGPLLYENITFVYNSEQL NGTQRVLLDNVLSEEQCREL HSVASGIMLVGDGYRGKTSP HTPNEKFEGATVLKALKSGY EGRVPLKSARLFYDISEKAR RIVESYFMLNSTLYFSYTHM VCRTALSGQQDRRNDLSHPI HADNCLLDPEANECWKEPPA YTFRDYSALLYMNDDFEGGE FIFTEMDAKTVTASIKPKC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human LEPREL1 (NP_060662.2). |
Additional Info
| Tissue Specificity | Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells (at protein level). Expressed in adult heart, placenta, lung, liver, skeletal muscle and kidney. Detected in fetal heart, spleen, lung, liver skeletal muscle and kidney. |
| Function | Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule. Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position. |
| Protein Name | Prolyl 3-Hydroxylase 2Leprecan-Like Protein 1Myxoid Liposarcoma-Associated Protein 4 |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumGolgi Apparatus |
| Alternative Antibody Names | Anti-Prolyl 3-Hydroxylase 2 antibodyAnti-Leprecan-Like Protein 1 antibodyAnti-Myxoid Liposarcoma-Associated Protein 4 antibodyAnti-P3H2 antibodyAnti-LEPREL1 antibodyAnti-MLAT4 antibody |
Information sourced from Uniprot.org