Anti-LDLR antibody [PT1074R] (STJA0039980)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Low-Density Lipoprotein Receptor for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT1074R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:1000-1:4000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LDLR |
| Gene ID | 3949 |
| Uniprot ID | LDLR_HUMAN |
| Specificity | Endogenous |
Additional Info
| Function | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. |
| Protein Name | Low-Density Lipoprotein ReceptorLdl Receptor |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8964026Reactome: R-HSA-8964038Reactome: R-HSA-975634 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneClathrin-Coated PitGolgi ApparatusEarly EndosomeLate EndosomeLysosomeRapidly Endocytosed Upon Ligand BindingLocalized At Cell MembraneProbably In Lipid RaftsIn Serum-Starved Conditions |
| Alternative Antibody Names | Anti-Low-Density Lipoprotein Receptor antibodyAnti-Ldl Receptor antibodyAnti-LDLR antibody |
Information sourced from Uniprot.org