Anti-LDB1 antibody (1-50) (STJ119652)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LDB1 (1-50) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LDB1 |
| Gene ID | 8861 |
| Uniprot ID | LDB1_HUMAN |
| Immunogen Region | 1-50 |
| Immunogen Sequence | MLDRDVGPTPMYPPTYLEPG IGRHTPYGNQTDYRIFELNK RLQNWTEECD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-50 of human LDB1 (NP_003884.1). |
Additional Info
| Tissue Specificity | Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. |
| Post Translational Modifications | Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. |
| Function | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. |
| Protein Name | Lim Domain-Binding Protein 1Ldb-1Carboxyl-Terminal Lim Domain-Binding Protein 2Clim-2Lim Domain-Binding Factor Clim2Hldb1Nuclear Lim Interactor |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9010553Reactome: R-HSA-9733709Reactome: R-HSA-9752946 |
| Cellular Localisation | NucleusColocalizes With Slk At Leading Edges |
| Alternative Antibody Names | Anti-Lim Domain-Binding Protein 1 antibodyAnti-Ldb-1 antibodyAnti-Carboxyl-Terminal Lim Domain-Binding Protein 2 antibodyAnti-Clim-2 antibodyAnti-Lim Domain-Binding Factor Clim2 antibodyAnti-Hldb1 antibodyAnti-Nuclear Lim Interactor antibodyAnti-LDB1 antibodyAnti-CLIM2 antibody |
Information sourced from Uniprot.org