Anti-LAT2 antibody (Internal) (STJ72991)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-LAT2 (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/IF/FC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx. 26kDa band observed in Human Peripheral Blood Monocytes lysates and Human Spleen, and approx. 30kDa in lysates of cell lines Daudi and U937 (calculated MW of 26.6kDa according |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | LAT2 |
| Gene ID | 7462 |
| Uniprot ID | NTAL_HUMAN |
| Accession Number | NP_054865.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | RSEKIYQQRSLRED |
| Specificity | Reported variants represent identical protein: NP_115853.2, NP_115852.1, NP_054865.2 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells.which induces the recruitment of GRB2. May be polyubiquitinated. |
| Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
| Protein Name | Linker For Activation Of T-Cells Family Member 2Linker For Activation Of B-CellsMembrane-Associated Adapter MoleculeNon-T-Cell Activation LinkerWilliams-Beuren Syndrome Chromosomal Region 15 ProteinWilliams-Beuren Syndrome Chromosomal Region 5 Protein |
| Database Links | Reactome: R-HSA-2730905 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Antibody Names | Anti-Linker For Activation Of T-Cells Family Member 2 antibodyAnti-Linker For Activation Of B-Cells antibodyAnti-Membrane-Associated Adapter Molecule antibodyAnti-Non-T-Cell Activation Linker antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 15 Protein antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 5 Protein antibodyAnti-LAT2 antibodyAnti-LAB antibodyAnti-NTAL antibodyAnti-WBS15 antibodyAnti-WBSCR15 antibodyAnti-WBSCR5 antibodyAnti-HSPC046 antibody |
Information sourced from Uniprot.org