Anti-LASS1 antibody (Internal) (STJ71677)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-LASS1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx. 37 kDa band observed in Human Brain (Cerebellum, Cerebral Cortex and Frontal Cortex) lysates (calculated MW of 38.0 kDa according to NP_937850.1) An additional band of unknown |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CERS1 |
| Gene ID | 10715 |
| Uniprot ID | CERS1_HUMAN |
| Accession Number | NP_067090.1; NP_937850.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | KDLREYDTAEAQ |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_067090.1and NP_937850.1). |
Additional Info
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA.C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way. Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function. In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. |
| Protein Name | Ceramide Synthase 1Cers1Lag1 Longevity Assurance Homolog 1Longevity Assurance Gene 1 Protein Homolog 1Protein Uog-1Sphingoid Base N-Stearoyltransferase Cers1 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 1 antibodyAnti-Cers1 antibodyAnti-Lag1 Longevity Assurance Homolog 1 antibodyAnti-Longevity Assurance Gene 1 Protein Homolog 1 antibodyAnti-Protein Uog-1 antibodyAnti-Sphingoid Base N-Stearoyltransferase Cers1 antibodyAnti-CERS1 antibodyAnti-LAG1 antibodyAnti-LASS1 antibodyAnti-UOG1 antibody |
Information sourced from Uniprot.org