| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-LASS1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CERS1 |
| Gene ID: |
10715 |
| Uniprot ID: |
CERS1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_067090.1; NP_937850.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_067090.1and NP_937850.1). |
| Immunogen Sequence: |
KDLREYDTAEAQ |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA.C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way. Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function. In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. |
| Protein Name | Ceramide Synthase 1Cers1Lag1 Longevity Assurance Homolog 1Longevity Assurance Gene 1 Protein Homolog 1Protein Uog-1Sphingoid Base N-Stearoyltransferase Cers1 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 1 antibodyAnti-Cers1 antibodyAnti-Lag1 Longevity Assurance Homolog 1 antibodyAnti-Longevity Assurance Gene 1 Protein Homolog 1 antibodyAnti-Protein Uog-1 antibodyAnti-Sphingoid Base N-Stearoyltransferase Cers1 antibodyAnti-CERS1 antibodyAnti-LAG1 antibodyAnti-LASS1 antibodyAnti-UOG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
