| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA.C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way. Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function. In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. |
| Protein Name | Ceramide Synthase 1Cers1Lag1 Longevity Assurance Homolog 1Longevity Assurance Gene 1 Protein Homolog 1Protein Uog-1Sphingoid Base N-Stearoyltransferase Cers1 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 1 antibodyAnti-Cers1 antibodyAnti-Lag1 Longevity Assurance Homolog 1 antibodyAnti-Longevity Assurance Gene 1 Protein Homolog 1 antibodyAnti-Protein Uog-1 antibodyAnti-Sphingoid Base N-Stearoyltransferase Cers1 antibodyAnti-CERS1 antibodyAnti-LAG1 antibodyAnti-LASS1 antibodyAnti-UOG1 antibody |
Information sourced from Uniprot.org
