Anti-LARS antibody (1-270) (STJ117090)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LARS (1-270) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LARS1 |
| Gene ID | 51520 |
| Uniprot ID | SYLC_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MAERKGTAKVDFLKKIEKEI QQKWDTERVFEVNASNLEKQ TSKGKYFVTFPYPYMNGRLH LGHTFSLSKCEFAVGYQRLK GKCCLFPFGLHCTGMPIKAC ADKLKREIELYGCPPDFPDE EEEEEETSVKTEDIIIKDKA KGKKSKAAAKAGSSKYQWGI MKSLGLSDEEIVKFSEAEHW LDYFPPLAIQDLKRMGLKVD WRRSFITTDVNPYYDSFVRW QFLTLRERNKIKFGKRYTI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LARS (NP_064502.9). |
Additional Info
| Function | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate.then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing). |
| Protein Name | Leucine--Trna Ligase - CytoplasmicLeucyl-Trna SynthetaseLeursClrs |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leucine--Trna Ligase - Cytoplasmic antibodyAnti-Leucyl-Trna Synthetase antibodyAnti-Leurs antibodyAnti-Clrs antibodyAnti-LARS1 antibodyAnti-KIAA1352 antibodyAnti-LARS antibody |
Information sourced from Uniprot.org