| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LARP7 (160-380) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LARP7 |
| Gene ID: |
51574 |
| Uniprot ID: |
LARP7_HUMAN |
| Immunogen Region: |
160-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-380 of human LARP7 (NP_057732.2). |
| Immunogen Sequence: |
KSTGDPKGFAFVEFETKEQA AKAIEFLNNPPEEAPRKPGI FPKTVKNKPIPALRVVEEKK KKKKKKGRMKKEDNIQAKEE NMDTSNTSISKMKRSRPTSE GSDIESTEPQKQCSKKKKKR DRVEASSLPEVRTGKRKRSS SEDAESLAPRSKVKKIIQKD IIKEASEASKENRDIEISTE EEKDTGDLKDSSLLKTKRKH KKKHKERHKMGEEVIPLRVL S |
| Function | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA.on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis. |
| Protein Name | La-Related Protein 7La Ribonucleoprotein Domain Family Member 7Hlarp7P-Tefb-Interaction Protein For 7sk StabilityPip7s |
| Cellular Localisation | NucleusNucleoplasm |
| Alternative Antibody Names | Anti-La-Related Protein 7 antibodyAnti-La Ribonucleoprotein Domain Family Member 7 antibodyAnti-Hlarp7 antibodyAnti-P-Tefb-Interaction Protein For 7sk Stability antibodyAnti-Pip7s antibodyAnti-LARP7 antibodyAnti-HDCMA18P antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
