Anti-LARGE1 antibody (STJA0009340)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LARGE
General Information
| Short Description | Rabbit polyclonal anti-Xylosyl-and glucuronyltransferase LARGE1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LARGE1 |
| Gene ID | 9215 |
| Uniprot ID | LARG1_HUMAN |
| Immunogen | Synthesized peptide derived from human LARGE |
| Specificity | This antibody detects endogenous levels of LARGE at Human, Mouse |
Additional Info
| Function | Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units -3-Xylose-alpha-1,3-GlcA-beta-1- to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer. Plays a key role in skeletal muscle function and regeneration. |
| Protein Name | Xylosyl- And Glucuronyltransferase Large1Acetylglucosaminyltransferase-Like 1aGlycosyltransferase-Like ProteinLarge Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 |
| Database Links | Reactome: R-HSA-5083627Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Xylosyl- And Glucuronyltransferase Large1 antibodyAnti-Acetylglucosaminyltransferase-Like 1a antibodyAnti-Glycosyltransferase-Like Protein antibodyAnti-Large Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 antibodyAnti-LARGE1 antibodyAnti-KIAA0609 antibodyAnti-LARGE antibody |
Information sourced from Uniprot.org