| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Mouse/Rat/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-LARGE (N-Term) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
LARGE1 |
| Gene ID: |
9215 |
| Uniprot ID: |
LARG1_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_004728.1 |
| Specificity: |
Reported variants represent identical protein: NP_004728.1, NP_598397.1 |
| Immunogen Sequence: |
RYTASSQRERESLE |
| Function | Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units -3-Xylose-alpha-1,3-GlcA-beta-1- to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer. Plays a key role in skeletal muscle function and regeneration. |
| Protein Name | Xylosyl- And Glucuronyltransferase Large1Acetylglucosaminyltransferase-Like 1aGlycosyltransferase-Like ProteinLarge Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 |
| Database Links | Reactome: R-HSA-5083627Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Xylosyl- And Glucuronyltransferase Large1 antibodyAnti-Acetylglucosaminyltransferase-Like 1a antibodyAnti-Glycosyltransferase-Like Protein antibodyAnti-Large Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 antibodyAnti-LARGE1 antibodyAnti-KIAA0609 antibodyAnti-LARGE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
