Anti-Langerin antibody IHC human Langerhans cell histiocytosis STJ180613

Anti-Langerin antibody (50-250) [ZR170] (STJ180613)

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STJ180613
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal Langerin (50-250) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : ZR170
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: CD207
Gene ID: 50489
Uniprot ID: CLC4K_HUMAN
Immunogen Region: 50-250
Specificity: Positive Control: skin/Langerhans cell histiocytosis
Immunogen: Recombinant fragment (around aa50-250) of human Langerin protein
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Protein Name C-Type Lectin Domain Family 4 Member K
Langerin
Cd Antigen Cd207
Database Links Reactome: R-HSA-1236978
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Found In Birbeck Granules (Bgs)
Which Are Organelles Consisting Of Superimposed And Zippered Membranes
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member K antibody
Anti-Langerin antibody
Anti-Cd Antigen Cd207 antibody
Anti-CD207 antibody
Anti-CLEC4K antibody

Information sourced from Uniprot.org

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