Anti-LAMTOR5/HBXIP antibody (Met1-Ser91) [1A071] (STJA0021909)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenE coli-derived recombinant Human LAMTOR5/HBXIP (Met1-Ser91)
General Information
| Short Description | Mouse monoclonal Ragulator Complex Protein Lamtor5 (Met1-Ser91) antibody for use in ELISA, IHC and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IHC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1A071 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | LAMTOR5 |
| Gene ID | 10542 |
| Uniprot ID | LTOR5_HUMAN |
| Immunogen | E coli-derived recombinant Human LAMTOR5/HBXIP (Met1-Ser91) |
| Immunogen Region | Met1-Ser91 |
Additional Info
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. |
| Protein Name | Ragulator Complex Protein Lamtor5Hepatitis B Virus X-Interacting ProteinHbv X-Interacting ProteinHbx-Interacting ProteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | LysosomeCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor5 antibodyAnti-Hepatitis B Virus X-Interacting Protein antibodyAnti-Hbv X-Interacting Protein antibodyAnti-Hbx-Interacting Protein antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 antibodyAnti-LAMTOR5 antibodyAnti-HBXIP antibodyAnti-XIP antibody |
Information sourced from Uniprot.org