| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Lamp1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Lamp1 |
| Gene ID: |
16783 |
| Uniprot ID: |
LAMP1_MOUSE |
| Specificity: |
Specific for Lamp1. |
| Immunogen: |
A synthetic peptide to from second lumenal domain of mouse Lamp1 (CD107a) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat. |
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 1Lamp-1Lysosome-Associated Membrane Protein 1120 Kda Lysosomal Membrane GlycoproteinCd107 Antigen-Like Family Member ALgp-120Lysosomal Membrane Glycoprotein ALgp-AP2bCd Antigen Cd107a |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneLate Endosome MembraneCell MembraneCytolytic Granule MembraneThis Protein Shuttles Between LysosomesEndosomesAnd The Plasma MembraneColocalizes With Osbpl1a At The Late Endosome |
| Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 1 antibodyAnti-Lamp-1 antibodyAnti-Lysosome-Associated Membrane Protein 1 antibodyAnti-120 Kda Lysosomal Membrane Glycoprotein antibodyAnti-Cd107 Antigen-Like Family Member A antibodyAnti-Lgp-120 antibodyAnti-Lysosomal Membrane Glycoprotein A antibodyAnti-Lgp-A antibodyAnti-P2b antibodyAnti-Cd Antigen Cd107a antibodyAnti-Lamp1 antibodyAnti-Lamp-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-LAMP1 antibody [SM4995] (STJA0004995)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/180058/403329/STJA0004995_1__08158.1738950397.png?c=1 "Anti-LAMP1 antibody [SM4995] (STJA0004995)")
