Anti-Lambda Light Chain antibody [LCN-2] (STJ16101848)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenPurified human IgG myeloma proteins coupled to polyaminostyren microbeads
General Information
| Short Description | Mouse monoclonal anti-Lambda Light Chain for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | LCN-2 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Purification | Concentrate |
| Dilution Range | IHC-P 1:200-1:400 |
| Formulation | Bioreactor Concentrate with 0.05% Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Purified human IgG myeloma proteins coupled to polyaminostyren microbeads |
Additional Info
| Background | This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, or in 50 mM Tris buffer pH9.5, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue HEK293T, Tonsil, Spleen |
Information sourced from Uniprot.org