Anti-Lactoperoxidase antibody (Internal) (STJ71524)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Lactoperoxidase (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 70-75kDa band observed in Human Lung lysates (calculated MW of 80.3kDa according to NP_006142.1). Recommended concentration: 0.01-0.03µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | LPO |
| Gene ID | 4025 |
| Uniprot ID | PERL_HUMAN |
| Accession Number | NP_006142.1 |
| Immunogen Region | Internal |
| Specificity | This antibody is expected to recognise isoform 1 (NP_006142.1) only. |
Additional Info
| Function | Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2. Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism. Shows antibacterial properties against Pseudomonas aeruginosa. The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro. Present in mammary and salivary gland secretions and may contribute to airway host defense against infection. May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation. |
| Protein Name | LactoperoxidaseLpoSalivary PeroxidaseSpo |
| Database Links | Reactome: R-HSA-8941413 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Lactoperoxidase antibodyAnti-Lpo antibodyAnti-Salivary Peroxidase antibodyAnti-Spo antibodyAnti-LPO antibodyAnti-SAPX antibody |
Information sourced from Uniprot.org