Anti-LACTB antibody (120-290) (STJ11102333)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LACTB (120-290) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LACTB |
| Gene ID | 114294 |
| Uniprot ID | LACTB_HUMAN |
| Immunogen Region | 120-290 |
| Immunogen Sequence | DEVGAPGIVVGVSVDGKEVW SEGLGYADVENRVPCKPETV MRIASISKSLTMVALAKLWE AGKLDLDIPVQHYVPEFPEK EYEGEKVSVTTRLLISHLSG IRHYEKDIKKVKEEKAYKAL KMMKENVAFEQEKEGKSNEK NDFTKFKTEQENEAKCRNSK PGKKKNDFEQG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-290 of human LACTB (NP_116246.2). |
Additional Info
| Tissue Specificity | Expressed predominantly in skeletal muscle. |
| Function | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism. |
| Protein Name | Serine Beta-Lactamase-Like Protein Lactb - Mitochondrial |
| Database Links | |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Serine Beta-Lactamase-Like Protein Lactb - Mitochondrial antibodyAnti-LACTB antibodyAnti-MRPL56 antibodyAnti-UNQ843 antibodyAnti-PRO1781 antibody |
Information sourced from Uniprot.org