| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LACTB (120-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LACTB |
| Gene ID: |
114294 |
| Uniprot ID: |
LACTB_HUMAN |
| Immunogen Region: |
120-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-290 of human LACTB (NP_116246.2). |
| Immunogen Sequence: |
DEVGAPGIVVGVSVDGKEVW SEGLGYADVENRVPCKPETV MRIASISKSLTMVALAKLWE AGKLDLDIPVQHYVPEFPEK EYEGEKVSVTTRLLISHLSG IRHYEKDIKKVKEEKAYKAL KMMKENVAFEQEKEGKSNEK NDFTKFKTEQENEAKCRNSK PGKKKNDFEQG |
| Tissue Specificity | Expressed predominantly in skeletal muscle. |
| Function | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism. |
| Protein Name | Serine Beta-Lactamase-Like Protein Lactb - Mitochondrial |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Serine Beta-Lactamase-Like Protein Lactb - Mitochondrial antibodyAnti-LACTB antibodyAnti-MRPL56 antibodyAnti-UNQ843 antibodyAnti-PRO1781 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
