Anti-L3MBTL2 antibody (486-705) (STJ112369)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal L3MBTL2 (486-705) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | L3MBTL2 |
| Gene ID | 83746 |
| Uniprot ID | LMBL2_HUMAN |
| Immunogen Region | 486-705 |
| Immunogen Sequence | PATFCQKNDIELTPPKGYEA QTFNWENYLEKTKSKAAPSR LFNMDCPNHGFKVGMKLEAV DLMEPRLICVATVKRVVHRL LSIHFDGWDSEYDQWVDCES PDIYPVGWCELTGYQLQPPV AAEPATPLKAKEATKKKKKQ FGKKRKRIPPTKTRPLRQGS KKPLLEDDPQGARKISSEPV PGEIIAVRVKEEHLDVASPD KASSPELPVSVENIKQETDD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2). |
Additional Info
| Function | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. |
| Protein Name | Lethal(3malignant Brain Tumor-Like Protein 2H-L(3mbt-Like Protein 2L(3mbt-Like Protein 2 |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lethal(3malignant Brain Tumor-Like Protein 2 antibodyAnti-H-L(3mbt-Like Protein 2 antibodyAnti-L(3mbt-Like Protein 2 antibodyAnti-L3MBTL2 antibody |
Information sourced from Uniprot.org