Anti-L1CAM antibody (Extracellular region) [M023] (STJA0005457)

SKU:
STJA0005457-100

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Host: Mouse
Applications: WB/ICC/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-L1CAM (Extracellular region) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: M023
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC 1:100
IP 1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: L1CAM
Gene ID: 3897
Uniprot ID: L1CAM_HUMAN
Immunogen Region: Extracellular region
Specificity: Clone M023 mouse monoclonal antibody detects a 230 kDa* protein on SDS-PAGE immunoblots of human MeWo, MDA-MB-231, A431, and MCF7 cells, as well as human brain tissue. The antibody works for western blot, immunoprecipitation, ELISA, and immunocytoche
Immunogen: Clone (M023) was generated from a proprietary antigen related to the native human L1CAM expressed in the MeWo melanoma cell line.
Function Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Protein Name Neural Cell Adhesion Molecule L1
N-Cam-L1
Ncam-L1
Cd Antigen Cd171
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-373760
Reactome: R-HSA-437239
Reactome: R-HSA-445095
Reactome: R-HSA-445144
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Growth Cone
Axon
Dendrite
Colocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal Neurons
In Neurons
Detected Predominantly In Axons And Cell Body
Weak Localization To Dendrites
Alternative Antibody Names Anti-Neural Cell Adhesion Molecule L1 antibody
Anti-N-Cam-L1 antibody
Anti-Ncam-L1 antibody
Anti-Cd Antigen Cd171 antibody
Anti-L1CAM antibody
Anti-CAML1 antibody
Anti-MIC5 antibody

Information sourced from Uniprot.org

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