| Host: |
Mouse |
| Applications: |
WB/ICC/IP |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-L1CAM (Extracellular region) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M023 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:1000IHCICC 1:100IP 1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
L1CAM |
| Gene ID: |
3897 |
| Uniprot ID: |
L1CAM_HUMAN |
| Immunogen Region: |
Extracellular region |
| Specificity: |
Clone M023 mouse monoclonal antibody detects a 230 kDa* protein on SDS-PAGE immunoblots of human MeWo, MDA-MB-231, A431, and MCF7 cells, as well as human brain tissue. The antibody works for western blot, immunoprecipitation, ELISA, and immunocytoche |
| Immunogen: |
Clone (M023) was generated from a proprietary antigen related to the native human L1CAM expressed in the MeWo melanoma cell line. |
| Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
| Protein Name | Neural Cell Adhesion Molecule L1N-Cam-L1Ncam-L1Cd Antigen Cd171 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-373760Reactome: R-HSA-437239Reactome: R-HSA-445095Reactome: R-HSA-445144 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionGrowth ConeAxonDendriteColocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal NeuronsIn NeuronsDetected Predominantly In Axons And Cell BodyWeak Localization To Dendrites |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule L1 antibodyAnti-N-Cam-L1 antibodyAnti-Ncam-L1 antibodyAnti-Cd Antigen Cd171 antibodyAnti-L1CAM antibodyAnti-CAML1 antibodyAnti-MIC5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
