Anti-L1CAM antibody [1H3] (STJA0032662)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human L1CAM produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-L1CAM for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1H3 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | L1CAM |
| Gene ID | 3897 |
| Uniprot ID | L1CAM_HUMAN |
| Immunogen | Full length human recombinant protein of human L1CAM produced in 293T cell. |
Additional Info
| Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
| Protein Name | Neural Cell Adhesion Molecule L1N-Cam-L1Ncam-L1Cd Antigen Cd171 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-373760Reactome: R-HSA-437239Reactome: R-HSA-445095Reactome: R-HSA-445144 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionGrowth ConeAxonDendriteColocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal NeuronsIn NeuronsDetected Predominantly In Axons And Cell BodyWeak Localization To Dendrites |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule L1 antibodyAnti-N-Cam-L1 antibodyAnti-Ncam-L1 antibodyAnti-Cd Antigen Cd171 antibodyAnti-L1CAM antibodyAnti-CAML1 antibodyAnti-MIC5 antibody |
Information sourced from Uniprot.org