| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5268RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KYNU |
| Gene ID: | 8942 |
| Uniprot ID: | KYNU_HUMAN |
| Immunogen Region: | 1-465 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-465 of human KYNU (NP_003928.1). |
| Immunogen Sequence: | MEPSSLELPADTVQRIAAEL KCHPTDERVALHLDEEDKLR HFRECFYIPKIQDLPPVDLS LVNKDENAIYFLGNSLGLQP KMVKTYLEEELDKWAKIAAY GHEVGKRPWITGDESIVGLM KDIVGANEKEIALMNALTVN LHLLMLSFFKPTPKRYKILL EAKAFPSDHYAIESQLQLHG LNIEESMRMIKPREGEETLR IEDILEVIEKEGDSIAVILF SGVHFYTGQHFNIPAITKA |
| Tissue Specificity | Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. |
| Function | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Protein Name | KynureninaseL-Kynurenine Hydrolase |
| Database Links | Reactome: R-HSA-71240 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Kynureninase antibodyAnti-L-Kynurenine Hydrolase antibodyAnti-KYNU antibody |
Information sourced from Uniprot.org