Anti-KYNU antibody (1-307) (STJ28726)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KYNU (1-307) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KYNU |
| Gene ID | 8942 |
| Uniprot ID | KYNU_HUMAN |
| Immunogen Region | 1-307 |
| Immunogen Sequence | MEPSSLELPADTVQRIAAEL KCHPTDERVALHLDEEDKLR HFRECFYIPKIQDLPPVDLS LVNKDENAIYFLGNSLGLQP KMVKTYLEEELDKWAKIAAY GHEVGKRPWITGDESIVGLM KDIVGANEKEIALMNALTVN LHLLMLSFFKPTPKRYKILL EAKAFPSDHYAIESQLQLHG LNIEESMRMIKPREGEETLR IEDILEVIEKEGDSIAVILF SGVHFYTGQHFNIPAITKA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human KYNU (NP_001028170.1). |
Additional Info
| Tissue Specificity | Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. |
| Function | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Protein Name | KynureninaseL-Kynurenine Hydrolase |
| Database Links | Reactome: R-HSA-71240 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Kynureninase antibodyAnti-L-Kynurenine Hydrolase antibodyAnti-KYNU antibody |
Information sourced from Uniprot.org