| Host: |
Mouse |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Keratin, type II cytoskeletal 8 (400-483 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ABT534 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2bk |
| Formulation: |
Liquid in PBS pH7.2, 0.03% Proclin 300, with stabilizing protein. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:200-400WB 1:200-1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KRT8 |
| Gene ID: |
3856 |
| Uniprot ID: |
K2C8_HUMAN |
| Immunogen Region: |
400-483 aa |
| Specificity: |
The antibody can specifically recognize human CK8 protein, and shows no cross reaction with CK1, 4, 5, 6, 7, 10, 15, 16, 17, 18, 20. |
| Immunogen: |
Synthesized peptide derived from the human Cytokeratin 8 at the amino acid range 400-483 |
| Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Protein Name | Keratin - Type Ii Cytoskeletal 8Cytokeratin-8Ck-8Keratin-8K8Type-Ii Keratin Kb8 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus Matrix |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibodyAnti-Cytokeratin-8 antibodyAnti-Ck-8 antibodyAnti-Keratin-8 antibodyAnti-K8 antibodyAnti-Type-Ii Keratin Kb8 antibodyAnti-KRT8 antibodyAnti-CYK8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
