Anti-KRT2 antibody (1-220) (STJ112411)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KRT2 (1-220) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KRT2 |
| Gene ID | 3849 |
| Uniprot ID | K22E_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MSCQISCKSRGRGGGGGGFR GFSSGSAVVSGGSRRSTSSF SCLSRHGGGGGGFGGGGFGS RSLVGLGGTKSISISVAGGG GGFGAAGGFGGRGGGFGGGS SFGGGSGFSGGGFGGGGFGG GRFGGFGGPGGVGGLGGPGG FGPGGYPGGIHEVSVNQSLL QPLNVKVDPEIQNVKAQERE QIKTLNNKFASFIDKVRFLE QQNQVLQTKWELLQQMNVGT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Cytokeratin 2e (KRT2) (NP_000414.2). |
Additional Info
| Tissue Specificity | Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. |
| Function | Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins. Plays a role in the establishment of the epidermal barrier on plantar skin. |
| Protein Name | Keratin - Type Ii Cytoskeletal 2 EpidermalCytokeratin-2eCk-2eEpithelial Keratin-2eKeratin-2 EpidermisKeratin-2eK2eType-Ii Keratin Kb2 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 2 Epidermal antibodyAnti-Cytokeratin-2e antibodyAnti-Ck-2e antibodyAnti-Epithelial Keratin-2e antibodyAnti-Keratin-2 Epidermis antibodyAnti-Keratin-2e antibodyAnti-K2e antibodyAnti-Type-Ii Keratin Kb2 antibodyAnti-KRT2 antibodyAnti-KRT2A antibodyAnti-KRT2E antibody |
Information sourced from Uniprot.org