Anti-KPNA6 antibody (Internal) (STJ71571)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-KPNA6 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 60kDa band observed in Human Skeletal Muscle lysates (calculated MW of 60.0kDa according to NP_036448.1). Recommended concentration:0.1-0.3µg/ml.Some minor background is detect |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | KPNA6 |
| Gene ID | 23633 |
| Uniprot ID | IMA7_HUMAN |
| Accession Number | NP_036448.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | STTGESVITREMVE |
Additional Info
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Importin Subunit Alpha-7Karyopherin Subunit Alpha-6 |
| Database Links | Reactome: R-HSA-68616 |
| Alternative Antibody Names | Anti-Importin Subunit Alpha-7 antibodyAnti-Karyopherin Subunit Alpha-6 antibodyAnti-KPNA6 antibodyAnti-IPOA7 antibody |
Information sourced from Uniprot.org