| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Importin subunit alpha-5 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KPNA1 |
| Gene ID: |
3836 |
| Uniprot ID: |
IMA5_HUMAN |
| Specificity: |
IMA1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Polyubiquitinated in the presence of RAG1 (in vitro). |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
| Protein Name | Importin Subunit Alpha-5Karyopherin Subunit Alpha-1Nucleoprotein Interactor 1Npi-1Rag Cohort Protein 2Srp1-Beta Cleaved Into - Importin Subunit Alpha-5 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-140342Reactome: R-HSA-162592Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-180910Reactome: R-HSA-68616Reactome: R-HSA-909733Reactome: R-HSA-9636249 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin Subunit Alpha-5 antibodyAnti-Karyopherin Subunit Alpha-1 antibodyAnti-Nucleoprotein Interactor 1 antibodyAnti-Npi-1 antibodyAnti-Rag Cohort Protein 2 antibodyAnti-Srp1-Beta Cleaved Into - Importin Subunit Alpha-5 - N-Terminally Processed antibodyAnti-KPNA1 antibodyAnti-RCH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
