Anti-KNTC1 antibody (1343-1393 aa) (STJ196011)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human KNTC1 at the amino acid range 1343-1393
General Information
| Short Description | Rabbit polyclonal anti-Kinetochore-associated protein 1 (1343-1393 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KNTC1 |
| Gene ID | 9735 |
| Uniprot ID | KNTC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human KNTC1 at the amino acid range 1343-1393 |
| Immunogen Region | 1343-1393 aa |
| Specificity | This antibody detects endogenous levels of KNTC1 at Human/Mouse |
Additional Info
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. |
| Protein Name | Kinetochore-Associated Protein 1Rough Deal HomologHsrodRodHrod |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereKinetochoreCytoskeletonSpindleDynamic Pattern Of Localization During The Cell CycleAt InterphaseUniformly Distributed Throughout The Cytoplasm And NucleusBy Prophase And Until Late Stages Of PrometaphaseA Fraction Of The Total Pool Is Concentrated At KinetochoresBy MetaphaseDetected At KinetochoresAlong Spindle Fibers And Most Prominently At The PolesBy Late Anaphase Until The End Of TelophaseNo Longer Detectable On Kinetochores Or Along Spindle FibersBut Still Present At The Spindle Poles |
| Alternative Antibody Names | Anti-Kinetochore-Associated Protein 1 antibodyAnti-Rough Deal Homolog antibodyAnti-Hsrod antibodyAnti-Rod antibodyAnti-Hrod antibodyAnti-KNTC1 antibodyAnti-KIAA0166 antibodyAnti-ROD antibody |
Information sourced from Uniprot.org