| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Kinetochore scaffold 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KNL1 |
| Gene ID: |
57082 |
| Uniprot ID: |
KNL1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of CASC5/KNL1 at Human |
| Immunogen: |
Synthesized peptide derived from human CASC5/KNL1 |
| Function | Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. |
| Protein Name | Kinetochore Scaffold 1All1-Fused Gene From Chromosome 15q14 ProteinAf15q14Bub-Linking Kinetochore ProteinBlinkinCancer Susceptibility Candidate Gene 5 ProteinCancer/Testis Antigen 29Ct29Kinetochore-Null Protein 1Protein Casc5Protein D40/Af15q14 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreWeakly Expressed In Interphase NucleiExpression Increases From Prophase To Late AnaphaseBut Greatly Diminishes From The Telophase And Cytokinesis To Early G1 Phase Of Cell Cycle |
| Alternative Antibody Names | Anti-Kinetochore Scaffold 1 antibodyAnti-All1-Fused Gene From Chromosome 15q14 Protein antibodyAnti-Af15q14 antibodyAnti-Bub-Linking Kinetochore Protein antibodyAnti-Blinkin antibodyAnti-Cancer Susceptibility Candidate Gene 5 Protein antibodyAnti-Cancer/Testis Antigen 29 antibodyAnti-Ct29 antibodyAnti-Kinetochore-Null Protein 1 antibodyAnti-Protein Casc5 antibodyAnti-Protein D40/Af15q14 antibodyAnti-KNL1 antibodyAnti-CASC5 antibodyAnti-KIAA1570 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
