| Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. |
| Protein Name | Histone-Lysine N-Methyltransferase Kmt5bLysine N-Methyltransferase 5bLysine-Specific Methyltransferase 5bSuppressor Of Variegation 4-20 Homolog 1Su(Var4-20 Homolog 1Suv4-20h1Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5bHistone H4-Lysine20 N-Methyltransferase Kmt5b |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosomeAssociated With Pericentric HeterochromatinCbx1 And Cbx5 Are Required For The Localization To Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Kmt5b antibodyAnti-Lysine N-Methyltransferase 5b antibodyAnti-Lysine-Specific Methyltransferase 5b antibodyAnti-Suppressor Of Variegation 4-20 Homolog 1 antibodyAnti-Su(Var4-20 Homolog 1 antibodyAnti-Suv4-20h1 antibodyAnti-Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-Histone H4-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-KMT5B antibodyAnti-SUV420H1 antibodyAnti-CGI-85 antibody |
Information sourced from Uniprot.org
