| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SUV420H1 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KMT5B |
| Gene ID: |
51111 |
| Uniprot ID: |
KMT5B_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SUV420H1 (NP_060105.3). |
| Immunogen Sequence: |
MNTSAFPSRSSRHFSKSDSF SHNNPVRFRPIKGRQEELKE VIERFKKDEHLEKAFKCLTS GEWARHYFLNKNKMQEKLFK EHVFIYLRMFATDSGFEILP C |
| Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. |
| Protein Name | Histone-Lysine N-Methyltransferase Kmt5bLysine N-Methyltransferase 5bLysine-Specific Methyltransferase 5bSuppressor Of Variegation 4-20 Homolog 1Su(Var4-20 Homolog 1Suv4-20h1Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5bHistone H4-Lysine20 N-Methyltransferase Kmt5b |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosomeAssociated With Pericentric HeterochromatinCbx1 And Cbx5 Are Required For The Localization To Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Kmt5b antibodyAnti-Lysine N-Methyltransferase 5b antibodyAnti-Lysine-Specific Methyltransferase 5b antibodyAnti-Suppressor Of Variegation 4-20 Homolog 1 antibodyAnti-Su(Var4-20 Homolog 1 antibodyAnti-Suv4-20h1 antibodyAnti-Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-Histone H4-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-KMT5B antibodyAnti-SUV420H1 antibodyAnti-CGI-85 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
