| Tissue Specificity | Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Isoform NKp44L: Not detected on circulating cells from healthy individuals, but is expressed on a large panel of tumor and transformed cells. |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by USP7. O-glycosylated at Ser-435 and Thr-440 in the SET domain by OGT which probably prevents KMT2E proteasomal-mediated degradation. |
| Function | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Isoform NKp44L: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. |
| Protein Name | Inactive Histone-Lysine N-Methyltransferase 2eInactive Lysine N-Methyltransferase 2eMyeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 5 |
| Cellular Localisation | ChromosomeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleus SpeckleAbsent From The NucleolusLocalizes To Chromosome During Interphase And To Centrosomes During MitosisDissociation From Mitotic Chromosome Is Likely Due To Histone H3 Phosphorylation On 'Thr-3' And 'Thr-6'Isoform 3: NucleusNucleoplasmLocalizes To Chromosome During Interphase And To Nucleus Speckle During MitosisIsoform Nkp44l: CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Inactive Histone-Lysine N-Methyltransferase 2e antibodyAnti-Inactive Lysine N-Methyltransferase 2e antibodyAnti-Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 5 antibodyAnti-KMT2E antibodyAnti-MLL5 antibody |
Information sourced from Uniprot.org
