Host: | Rabbit |
Applications: | IHC/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Histone-lysine N-methyltransferase 2B (1060-1140 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC-P 1:50-300 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | KMT2B |
Gene ID: | 9757 |
Uniprot ID: | KMT2B_HUMAN |
Immunogen Region: | 1060-1140 aa |
Specificity: | MLL4 Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 1060-1140 |
Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. |
Protein Name | Histone-Lysine N-Methyltransferase 2b Lysine N-Methyltransferase 2b Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 4 Trithorax Homolog 2 Ww Domain-Binding Protein 7 Wbp-7 |
Database Links | Reactome: R-HSA-3214841 Reactome: R-HSA-8936459 Reactome: R-HSA-9772755 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase 2b antibody Anti-Lysine N-Methyltransferase 2b antibody Anti-Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 4 antibody Anti-Trithorax Homolog 2 antibody Anti-Ww Domain-Binding Protein 7 antibody Anti-Wbp-7 antibody Anti-KMT2B antibody Anti-HRX2 antibody Anti-KIAA0304 antibody Anti-MLL2 antibody Anti-MLL4 antibody Anti-TRX2 antibody Anti-WBP7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance